Clinician decision support · v1.2
Antidepressant Chooser
A structured way to turn response history, prior trials, safety, co-targets, tolerability, interactions, and age into a defensible starting option.
Treatment history
Was there a clear past benefit?
Consider the patient and first-degree relatives. A convincing prior response can be more useful than small average differences between medications.
References
Sources that support the pathway
These sources support safety screening, broad medication-selection principles, monitoring, and labeled indications. The exact branching and weighting are my synthesis and opinion.
Important
Use the result as a conversation starter.
Reassess suicidality, bipolar features, substance use, medical contributors, concurrent medications, adherence, and patient preference. For urgent safety concerns or diagnostic uncertainty, use the appropriate emergency or specialty pathway.